NIOSH Study Demonstrates Negative Effects of PFOA on Immune System of Mice

The National Institute for Occupational Safety and Health (NIOSH) has found significant health effects from dermal exposures to perfluorooctanoic acid (PFOA) in mice. PFOA was once commonly used in chemical polymerization and is now commonly found in the environment, wildlife and humans due to its long half-life.

While not irritating or sensitizing to the skin, the authors found significant effects on the immune system of mice exposed to high levels of PFOA over 4 days. Effects included a significant reduction in the weight of important immune organs (e.g. thymus, spleen); a reduction in immune cell counts (e.g. B-cells); and a reduction in important immune molecules (e.g. antibodies) in exposed mice. The authors also found that PFOA exposure resulted in significant changes in the expression of genes involved with ensuring the integrity of the skin. Together, the results raise concerns about potential adverse effects associated with dermal exposure to PFOA.